Xpert Mycobacterium tuberculosis/Rifampicin-Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications.

doi:10.1093/cid/ciaa873

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Xpert Mycobacterium tuberculosis/Rifampicin-Detected Rifampicin Resistance is a Suboptimal Surrogate for Multidrug-resistant Tuberculosis in Eastern Democratic Republic of the Congo: Diagnostic and Clinical Implications.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jul 2021

Bisimwa Bertin C, Nachega Jean B, Warren Robin M, Theron Grant, Metcalfe John Z, Shah Maunank, Diacon Andreas H, Sam-Agudu Nadia A, Yotebieng Marcel, Bulabula André N H, Katoto Patrick D M C, Chirambiza Jean-Paul, Nyota Rosette, Birembano Freddy M, Musafiri Eric M, Byadunia Sifa, Bahizire Esto, Kaswa Michel K, Callens Steven, Kashongwe Zacharie M

Abstract excerpt

BACKGROUND: Rifampicin (RIF) resistance is highly correlated with isoniazid (INH) resistance and used as proxy for multidrug-resistant tuberculosis (MDR-TB). Using MTBDRplus as a comparator, we evaluated the predictive value of Xpert MTB/RIF (Xpert)-detected RIF resistance for MDR-TB in eastern Democratic Republic of the Congo (DRC). METHODS: We conducted a cross-sectional study involving data from new or...

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PMID: 32590841
DOI: 10.1093/cid/ciaa873
PMCID: PMC8282324

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