Article
Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model.
JAMA cardiology - 1 Mar 2017
Arvanitis Marios, Koch Clarissa M, Chan Gloria G, Torres-Arancivia Celia, LaValley Michael P, Jacobson Daniel R, Berk John L, Connors Lawreen H, Ruberg Frederick L
Abstract excerpt
Importance: Transthyretin cardiac amyloidosis (ATTR) is an underrecognized cause of heart failure (HF) in older individuals, owing in part to difficulty in diagnosis. ATTR can result from substitution of valine for isoleucine at codon 122 of the transthyretin (TTR) gene (V122I), present in 3.43% of African American individuals. Objective: To examine whether serum retinol-binding protein 4 (RBP4), an endogenous...
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