Article
AURKA Overexpression Is Driven by FOXM1 and MAPK/ERK Activation in Melanoma Cells Harboring BRAF or NRAS Mutations: Impact on Melanoma Prognosis and Therapy.
The Journal of investigative dermatology - 1 Jun 2017
Puig-Butille Joan Anton, Vinyals Antònia, Ferreres Josep R, Aguilera Paula, Cabré Eduard, Tell-Martí Gemma, Marcoval Joaquim, Mateo Francesca, Palomero Luís, Badenas Celia, Piulats Josep M, Malvehy Josep, Pujana Miquel A, Puig Susana, Fabra Àngels
Abstract excerpt
The cell cycle-related genes AURKA and FOXM1 are overexpressed in melanoma. We show here that AURKA overexpression is associated with poor prognosis in three independent cohorts of melanoma patients and correlates with the presence of genomic amplification of AURKA locus and BRAFV600E mutation. AURKA overexpression may also be driven by increased promoter activation through elements such as ETS and FOXM1 found...
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