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Article

A Personalized Model of COQ2 Nephropathy Rescued by the Wild-Type COQ2 Allele or Dietary Coenzyme Q10 Supplementation.

Journal of the American Society of Nephrology : JASN - 1 Sept 2017

Zhu Jun-Yi, Fu Yulong, Richman Adam, Zhao Zhanzheng, Ray Patricio E, Han Zhe

Abstract excerpt

Clinical studies have identified patients with nephrotic syndrome caused by mutations in genes involved in the biosynthesis of coenzyme Q10 (CoQ10), a lipid component of the mitochondrial electron transport chain and an important antioxidant. However, the cellular mechanisms through which these mutations induce podocyte injury remain obscure. Here, we exploited the striking similarities between Drosophila...

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Identifiers

PMID: 28428331
DOI: 10.1681/ASN.2016060626
PMCID: PMC5576924

Genes

COQ2

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