Article
Angiogenesis and oxidative stress-related gene variants in recurrent pregnancy loss.
Reproduction, fertility, and development - 1 Mar 2018
Fortis Marcela Felix, Fraga Lucas Rosa, Boquett Juliano André, Kowalski Thayne Woycinck, Dutra Caroline Gross, Gonçalves Rozana Oliveira, Vianna Fernanda Sales Luiz, Schüler-Faccini Lavinia, Sanseverino Maria Teresa Vieira
Abstract excerpt
Recurrent pregnancy loss (RPL) affects ~3-5% of couples attempting to conceive and in around 50% of cases the aetiology remains unknown. Adequate vascularisation and placental circulation are indispensable for the development of a normal pregnancy. Prostaglandin-endoperoxide synthase 2 (PTGS2), vascular endothelial growth factor (VEGF) and the nitric oxide (NO) systems play important roles in reproductive...
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