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Human embryonic and induced pluripotent stem cells maintain phenotype but alter their metabolism after exposure to ROCK inhibitor.

Scientific reports - 6 Feb 2017

Vernardis Spyros I, Terzoudis Konstantinos, Panoskaltsis Nicki, Mantalaris Athanasios

Abstract excerpt

Human pluripotent stem cells (hPSCs) are adhesion-dependent cells that require cultivation in colonies to maintain growth and pluripotency. Robust differentiation protocols necessitate single cell cultures that are achieved by use of ROCK (Rho kinase) inhibitors. ROCK inhibition enables maintenance of stem cell phenotype; its effects on metabolism are unknown. hPSCs were exposed to 10 μM ROCK inhibitor for...

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PMID: 28165055
DOI: 10.1038/srep42138
PMCID: PMC5292706

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NANOG
SOX2
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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