Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach.

doi:10.1038/mt.2012.117

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Article

Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Oct 2012

Moschidou Dafni, Mukherjee Sayandip, Blundell Michael P, Drews Katharina, Jones Gemma N, Abdulrazzak Hassan, Nowakowska Beata, Phoolchund Anju, Lay Kenneth, Ramasamy T Selvee, Cananzi Mara, Nettersheim Daniel, Sullivan Mark, Frost Jennifer, Moore Gudrun, Vermeesch Joris R, Fisk Nicholas M, Thrasher Adrian J, Atala Anthony, Adjaye James, Schorle Hubert, De Coppi Paolo, Guillot Pascale V

Abstract excerpt

Induced pluripotent stem cells (iPSCs) with potential for therapeutic applications can be derived from somatic cells via ectopic expression of a set of limited and defined transcription factors. However, due to risks of random integration of the reprogramming transgenes into the host genome, the low efficiency of the process, and the potential risk of virally induced tumorigenicity, alternative methods have been...

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PMID: 22760542
DOI: 10.1038/mt.2012.117
PMCID: PMC3464631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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