Article
In situ pulmonary thrombosis and pulmonary embolus are distinct thrombotic phenotypes in critically ill patients with COVID-19 Acute Respiratory Distress Syndrome.
Journal of thrombosis and haemostasis : JTH - 1 Feb 2026
Aynekulu Mersha Daniël G, Lopuhaä Boaz, Gietema Hester A, Smit Jim, Wind Anne E, Hulshof Anne-Marije, Daenen Katrijn, Khyali Jessica, van Bussel Bas C T, van Oosterhout Matthijs F M, Moeniralam Hazra S, Kempers Eva K, Kruip Marieke J H A, Klok Frederikus A, Dalm Virgil A S H, Endeman Henrik, Van Gorp Eric C M, Dik Willem A, von der Thüsen Jan H, Juffermans Nicole P
Abstract excerpt
BACKGROUND: Pulmonary embolism (PE) is thought to originate from distal thrombosis. However, in hyperinflammatory conditions, such as COVID-19, thrombosis in the lung vasculature may occur independently of peripheral thrombosis, denoted as in situ thrombosis (IST). OBJECTIVES: We hypothesize that IST results from a dysregulated immune response involving both T-helper type 1 (Th1) and non-Th1 cell upregulation and...
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