Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.

Cell reports - 31 Jan 2017

Van de Pette Mathew, Abbas Allifia, Feytout Amelie, McNamara Gráinne, Bruno Ludovica, To Wilson K, Dimond Andrew, Sardini Alessandro, Webster Zoe, McGinty James, Paul Eleanor J, Ungless Mark A, French Paul M W, Withers Dominic J, Uren Anthony, Ferguson-Smith Anne C, Merkenschlager Matthias, John Rosalind M, Fisher Amanda G

Abstract excerpt

Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-specific reporters to non-invasively monitor imprinted Cdkn1c expression in mice and showed that expression was modulated by environmental factors encountered in utero. Acute exposure to chromatin-modifying drugs resulted in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p57

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Genetic Syndromes and Imprinting

Share to Genomic Imprinting

Source

Open in PubMed Open full text

Identifiers

PMID: 28147266
DOI: 10.1016/j.celrep.2017.01.010
PMCID: PMC5300902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.PMID 28147266Read ↗

Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes.Semantic proximity Read ↗

Environmental Exposure to Endocrine Disrupting Chemicals Influences Genomic Imprinting, Growth, and MetabolismSemantic proximity Read ↗

Bioluminescence as a tool for studying imprinted gene expressionSemantic proximity Read ↗

The impact of the fetal exposome as a predictor of cancer risk in childhood and adulthood. Aberrant epigenetic events occurring during gestation: May they trigger fetal programming of cancer risk later in life?Semantic proximity Read ↗

Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studiesSemantic proximity Read ↗

Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowthSemantic proximity Read ↗

Differentially Methylated Regions of Imprinted Genes in Prenatal, Perinatal and Postnatal Human TissuesSemantic proximity Read ↗

Epigenetics, human imprintome, and chronic diseasesSemantic proximity Read ↗

Genomic imprinting effects in a compromised in utero environment: Implications for a healthy pregnancySemantic proximity Read ↗

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolismSemantic proximity Read ↗

Advanced aging phenotype is revealed by epigenetic modifications in rat liver after in utero malnutrition.Semantic proximity Read ↗

Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.