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Multiple network algorithm for epigenetic modules via the integration of genome-wide DNA methylation and gene expression data

31 Jan 2017

Abstract excerpt

BACKGROUND: With the increase in the amount of DNA methylation and gene expression data, the epigenetic mechanisms of cancers can be extensively investigate. Available methods integrate the DNA methylation and gene expression data into a network by specifying the anti-correlation between them. However, the correlation between methylation and expression is usually unknown and difficult to determine. RESULTS: To...

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PMID: 28137264
DOI: 10.1186/s12859-017-1490-6

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