Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses.

Nature structural & molecular biology - 1 Mar 2017

Hummel Barbara, Hansen Erik C, Yoveva Aneliya, Aprile-Garcia Fernando, Hussong Rebecca, Sawarkar Ritwick

Abstract excerpt

Understanding how genotypes are linked to phenotypes is important in biomedical and evolutionary studies. The chaperone heat-shock protein 90 (HSP90) buffers genetic variation by stabilizing proteins with variant sequences, thereby uncoupling phenotypes from genotypes. Here we report an unexpected role of HSP90 in buffering cis-regulatory variation affecting gene expression. By using the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pairing
Share to DNA Transposable Elements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endogenous Retroviruses

Share to Histone-Lysine N-Methyltransferase

Share to HSP90 Heat-Shock Proteins

Share to Mammals

Share to Molecular Sequence Annotation

Share to Mutagenesis, Insertional

Source

Identifiers

PMID: 28134929
DOI: 10.1038/nsmb.3368

Genes

TRIM28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses.PMID 28134929Read ↗

The Hsp90 capacitor, developmental remodeling, and evolution: the robustness of gene networks and the curious evolvability of metamorphosis.Semantic proximity Read ↗

It's not magic - Hsp90 and its effects on genetic and epigenetic variation.Semantic proximity Read ↗

The Hsp90 Molecular Chaperone as a Global Modifier of the Genotype-Phenotype-Fitness Map: An Evolutionary Perspective.Semantic proximity Read ↗

Selection Transforms the Landscape of Genetic Variation Interacting with Hsp90.Semantic proximity Read ↗

HSP90 Shapes the Consequences of Human Genetic VariationSemantic proximity Read ↗

Trim28 is required for epigenetic stability during mouse oocyte to embryo transition.Semantic proximity Read ↗

Buffering role of HSP shapes the molecular evolution of mammalian and human genomes at short and long-term scalesSemantic proximity Read ↗

Genetic variation: HSP90 shapes human genetic variation.Semantic proximity Read ↗

Epigenetics is back! Hsp90 and phenotypic variation.Semantic proximity Read ↗

Hsp90 and developmental networks.Semantic proximity Read ↗

Modifiers of the Genotype-Phenotype Map: Hsp90 and Beyond.Semantic proximity Read ↗

Quantitative trait symmetry independent of Hsp90 buffering: distinct modes of genetic canalization and developmental stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.