Article
IL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis.
Scientific reports - 30 Jan 2017
Damen Michelle S M A, Agca Rabia, Holewijn Suzanne, de Graaf Jacqueline, Dos Santos Jéssica C, van Riel Piet L, Fransen Jaap, Coenen Marieke J H, Nurmohamed Mike T, Netea Mihai G, Dinarello Charles A, Joosten Leo A B, Heinhuis Bas, Popa Calin D
Abstract excerpt
Patients with rheumatoid arthritis (RA) are at higher risk of developing cardiovascular diseases (CVD). Interleukin (IL)-32 has previously been shown to be involved in the pathogenesis of RA and might be linked to the development of atherosclerosis. However, the exact mechanism linking IL-32 to CVD still needs to be elucidated. The influence of a functional genetic variant of IL-32 on lipid profiles and CVD risk...
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