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Article

SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment.

Stem cell reports - 14 Feb 2017

Dall Genevieve V, Vieusseux Jessica L, Korach Kenneth S, Arao Yukitomo, Hewitt Sylvia C, Hamilton Katherine J, Dzierzak Elaine, Boon Wah Chin, Simpson Evan R, Ramsay Robert G, Stein Torsten, Morris Joanne S, Anderson Robin L, Risbridger Gail P, Britt Kara L

Abstract excerpt

Estrogen stimulates breast development during puberty and mammary tumors in adulthood through estrogen receptor-α (ERα). These effects are proposed to occur via ERα+ luminal cells and not the mammary stem cells (MaSCs) that are ERαneg. Since ERα+ luminal cells express stem cell antigen-1 (SCA-1), we sought to determine if SCA-1 could define an ERα+ subset of EpCAM+/CD24+/CD49fhi MaSCs. We show that the MaSC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28132885
DOI: 10.1016/j.stemcr.2016.12.022
PMCID: PMC5312257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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