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Article

Downregulation of ALDH5A1 suppresses cisplatin resistance in esophageal squamous cell carcinoma by regulating ferroptosis signaling pathways

24 Jun 2024

Abstract excerpt

Abstract This study explores the specific role and underlying mechanisms of ALDH5A1 in the chemoresistance of esophageal squamous cell carcinoma (ESCC). The levels of cleaved caspase‐3, 4‐hydroxynonenal (4‐HNE), intracellular Fe2+, and lipid reactive oxygen species (ROS) were evaluated via immunofluorescence. Cell viability and migration were quantified using cell counting kit‐8 assays and wound healing assays,...

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PMID: 38923019
DOI: 10.1002/mc.23778

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