Article
Matrix metalloproteinase-1 promoter -1607 bp 1G/2G polymorphism associated with increased risk of spinal tuberculosis in Southern Chinese Han population.
Journal of clinical laboratory analysis - 1 Nov 2017
Zhou Ying, Gao Qile, He Dan, Deng Ang, Huang Rongfu, Li Yanbing, Tan Chunyan, Guo Chaofeng, Guo Qiang, Wang Longjie, Yang Guanteng, Zhang Hongqi
Abstract excerpt
BACKGROUND: Spinal tuberculosis is the most common form of musculoskeletal tuberculosis. The expression of matrix metalloproteinase-1 (MMP-1) is increased in cells with Mycobacterium tuberculosis infection. MMP-1 plays a curial role in extracellular matrix degradation during the progression of tuberculosis. Although the 1G/2G polymorphism in MMP-1-1607 influences its transcription, its role in spinal tuberculosis...
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