Article
Matrix metalloproteinase-1 polymorphism of promoter region in sarcoidosis and tuberculosis patients.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG - 1 Mar 2004
Ninomiya Shigemitsu, Niimi Takashi, Shimizu Shigeki, Sato Shigeki, Achiwa Hiroyuki, Ito Hidemi, Akita Kenji, Maeda Hiroyoshi, Ueda Ryuzo
Abstract excerpt
BACKGROUND AND AIM OF THE WORK: Matrix metalloproteinases (MMPs) are associated with several diseases. MMP-1 is one of the interstitial collagenases and the most highly expressed. Recent studies have found that a single nucleotide polymorphism located in the promoter region of the MMP-1 gene affects transcriptional activity. This polymorphism, 1G/2G, has been reported to associate with several malignant tumors...
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