Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus.

Journal of inherited metabolic disease - 1 Jan 2018

Bloom Kaitlyn, Mohsen Al-Walid, Karunanidhi Anuradha, El Demellawy Dina, Reyes-Múgica Miguel, Wang Yudong, Ghaloul-Gonzalez Lina, Otsubo Chikara, Tobita Kimi, Muzumdar Radhika, Gong Zhenwei, Tas Emir, Basu Shrabani, Chen Jie, Bennett Michael, Hoppel Charles, Vockley Jerry

Abstract excerpt

The Native American Pima population has the highest incidence of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) of any reported population, but the pathophysiologic mechanism is unknown. Genetic studies in Pima Indians have linked acyl-CoA dehydrogenase 10 (ACAD10) gene polymorphisms, among others, to this predisposition. The gene codes for a protein with a C-terminus region that is structurally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abdominal Fat
Share to Acyl-CoA Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adiposity

Share to Lipid Metabolism, Inborn Errors

Share to Mice, 129 Strain

Share to Mitochondria, Muscle

Share to Obesity, Abdominal

Share to Rhabdomyolysis

Source

Open in PubMed Open full text

Identifiers

PMID: 28120165
DOI: 10.1007/s10545-017-0013-y
PMCID: PMC5524623

Genes

ACAD10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus.PMID 28120165Read ↗

Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians.Semantic proximity Read ↗

Phenotype, genotype and long-term prognosis of 40 Chinese patients with isobutyryl-CoA dehydrogenase deficiency and a review of variant spectra in ACAD8.Semantic proximity Read ↗

ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathwaysSemantic proximity Read ↗

Isobutyryl-CoA dehydrogenase deficiency with a novel ACAD8 gene mutation detected by tandem mass spectrometry newborn screening.Semantic proximity Read ↗

Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I.Semantic proximity Read ↗

Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice.Semantic proximity Read ↗

Characterizing fatty acid oxidation genes in Drosophila.Semantic proximity Read ↗

Multiomics study of <i> CHCHD10 <sup>S59L</sup> </i> -related disease reveals energy metabolism downregulation: OXPHOS and β-oxidation deficiencies associated with lipids alterationsSemantic proximity Read ↗

Development and characterization of a mouse model for Acad9 deficiency.Semantic proximity Read ↗

Clinical, biochemical and genetic analyses in two Korean patients with medium-chain acyl-CoA dehydrogenase deficiency.Semantic proximity Read ↗

Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to Pcca mutation.Semantic proximity Read ↗

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.