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Article

MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis.

Journal of autoimmunity - 1 May 2017

Rajasekhar Megha, Olsson Anton M, Steel Kathryn J A, Georgouli Mirella, Ranasinghe Ushan, Brender Read Christine, Frederiksen Klaus S, Taams Leonie S

Abstract excerpt

Monocytes and macrophages are key mediators of inflammation in rheumatoid arthritis (RA). Their persistence at the inflammatory site is likely to contribute to immunopathology. We sought to characterise one mechanism by which persistence may be achieved: resistance to apoptosis and the role of mir-155 in this process. CD14+ monocytes from peripheral blood (PBM) and synovial fluid (SFM) of RA patients were found...

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Source

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Identifiers

PMID: 28118944
DOI: 10.1016/j.jaut.2017.01.002
PMCID: PMC5397583

Genes

APAF1
CASP10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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