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Article

Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells.

International journal of molecular sciences - 22 Jan 2017

Ye Yan, Qian Xue Yi, Xiao Miao Miao, Shao Yu Ling, Guo Li Mei, Liao Dong Ping, Da Jie, Zhang Lin Jie, Xu Jiegou

Abstract excerpt

Past studies have shown that the Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) is commonly downregulated in gastric cancer, which contributes to elevated activation of PI3K/Akt signaling, proliferation and tumorigenesis of gastric cancer cells. However, the mechanisms underlying the reduced expression of SHIP2 in gastric cancer remain unclear. While gene copy number variation analysis and exon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Share to Promoter Regions, Genetic

Share to Sp1 Transcription Factor

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Share to Transcription, Genetic

Source

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Identifiers

PMID: 28117748
DOI: 10.3390/ijms18010220
PMCID: PMC5297849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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