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Article

Incorporation of the time aspect into the liability-threshold model for case-control-family data.

Statistics in medicine - 10 May 2017

Cederkvist Luise, Holst Klaus K, Andersen Klaus K, Glidden David V, Frederiksen Kirsten, Kjaer Susanne K, Scheike Thomas H

Abstract excerpt

Familial aggregation and the role of genetic and environmental factors can be investigated through family studies analysed using the liability-threshold model. The liability-threshold model ignores the timing of events including the age of disease onset and right censoring, which can lead to estimates that are difficult to interpret and are potentially biased. We incorporate the time aspect into the...

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PMID: 28114748
DOI: 10.1002/sim.7229

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