Article
Validation of a clinical screening instrument for tumour predisposition syndromes in patients with childhood cancer (TuPS): protocol for a prospective, observational, multicentre study.
BMJ open - 20 Jan 2017
Postema Floor A M, Hopman Saskia M J, de Borgie Corianne A J M, Hammond Peter, Hennekam Raoul C, Merks Johannes H M, Aalfs Cora M, Anninga Jakob K, Berger Lieke Pv, Bleeker Fonnet E, de Bont Eveline Sjm, de Borgie Corianne Ajm, Dommering Charlotte J, van Eijkelenburg Natasha Ka, Hammond Peter, Hennekam Raoul C, van den Heuvel-Eibrink Marry M, Hopman Saskia Mj, Jongmans Marjolijn Cj, Kors Wijnanda A, Letteboer Tom Gw, Loeffen Jan Lcm, Merks Johannes Hm, Olderode-Berends Maran Jw, Postema Floor Am, Wagner Anja
Abstract excerpt
INTRODUCTION: Recognising a tumour predisposition syndrome (TPS) in patients with childhood cancer is of significant clinical relevance, as it affects treatment, prognosis and facilitates genetic counselling. Previous studies revealed that only half of the known TPSs are recognised during standard paediatric cancer care. In current medical practice it is impossible to refer every patient with childhood cancer to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.