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Article

NS5A resistance-associated substitutions in patients with genotype 1 hepatitis C virus: Prevalence and effect on treatment outcome.

Journal of hepatology - 1 May 2017

Zeuzem Stefan, Mizokami Masashi, Pianko Stephen, Mangia Alessandra, Han Kwang-Hyub, Martin Ross, Svarovskaia Evguenia, Dvory-Sobol Hadas, Doehle Brian, Hedskog Charlotte, Yun Chohee, Brainard Diana M, Knox Steven, McHutchison John G, Miller Michael D, Mo Hongmei, Chuang Wan-Long, Jacobson Ira, Dore Gregory J, Sulkowski Mark

Abstract excerpt

BACKGROUND & AIMS: The efficacy of NS5A inhibitors for the treatment of patients chronically infected with hepatitis C virus (HCV) can be affected by the presence of NS5A resistance-associated substitutions (RASs). We analyzed data from 35 phase I, II, and III studies in 22 countries to determine the pretreatment prevalence of various NS5A RASs, and their effect on outcomes of treatment with ledipasvir-sofosbuvir...

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Identifiers

PMID: 28108232
DOI: 10.1016/j.jhep.2017.01.007

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