Article
Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells.
Cancer science - 1 Apr 2017
Shikata Yuki, Kiga Masaki, Futamura Yushi, Aono Harumi, Inoue Hiroyuki, Kawada Manabu, Osada Hiroyuki, Imoto Masaya
Abstract excerpt
The wingless/int-1 (Wnt) signal transduction pathway plays a central role in cell proliferation, survival, differentiation and apoptosis. When β-catenin: a component of the Wnt pathway, is mutated into an active form, cell growth signaling is hyperactive and drives oncogenesis. As β-catenin is mutated in a wide variety of tumors, including up to 10% of all sporadic colon carcinomas and 20% of hepatocellular...
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