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Article

Regulatory single nucleotide polymorphisms (rSNPs) at the promoters 1A and 1B of the human APC gene.

BMC genetics - 22 Dec 2016

Matveeva Marina Yu, Kashina Elena V, Reshetnikov Vasily V, Bryzgalov Leonid O, Antontseva Elena V, Bondar Natalia P, Merkulova Tatiana I

Abstract excerpt

BACKGROUND: Germline mutations in the coding sequence of the tumour suppressor APC gene give rise to familial adenomatous polyposis (which leads to colorectal cancer) and are associated with many other oncopathologies. The loss of APC function because of deletion of putative promoter 1A or 1B also results in the development of colorectal cancer. Since the regions of promoters 1A and 1B contain many single...

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Identifiers

PMID: 28105931
DOI: 10.1186/s12863-016-0460-8
PMCID: PMC5249005

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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