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Utility of Assessing the Number of Mutated KRAS, CDKN2A, TP53, and SMAD4 Genes Using a Targeted Deep Sequencing Assay as a Prognostic Biomarker for Pancreatic Cancer.

Pancreas - 1 Mar 2017

Hayashi Hideyuki, Kohno Takashi, Ueno Hideki, Hiraoka Nobuyoshi, Kondo Shunsuke, Saito Motonobu, Shimada Yoko, Ichikawa Hitoshi, Kato Mamoru, Shibata Tatsuhiro, Morizane Chigusa, Sakamoto Yasunari, Shimada Kazuaki, Komatsu Yoshito, Sakamoto Naoya, Okusaka Takuji

Abstract excerpt

OBJECTIVES: KRAS, CDKN2A, TP53, and SMAD4 have been recognized as major driver genes in pancreatic carcinogenesis. We examined somatic mutations in 50 cancer-related genes, including the four above-mentioned driver genes, to identify genomic biomarkers for predicting the outcome of patients with pancreatic cancer. METHODS: Genomic DNA was extracted from fresh-frozen specimens obtained from 100 patients with...

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Identifiers

PMID: 28099251
DOI: 10.1097/MPA.0000000000000760

Genes

KRAS
SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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