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Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice

22 Aug 2009

Abstract excerpt

In mice and humans, the immunologic effects of developmental exposure to noninherited maternal antigens (NIMAs) are quite variable. This heterogeneity likely reflects differences in the relative levels of NIMA-specific T regulatory (T(R)) versus T effector (T(E)) cells. We hypothesized that maintenance of NIMA-specific T(R) cells in the adult requires continuous exposure to maternal cells and antigens (eg,...

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Identifiers

PMID: 19700665
DOI: 10.1182/blood-2009-03-213561

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