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Article

Stem cell microchimerism and tolerance to non-inherited maternal antigens

1 Jul 2010

Abstract excerpt

Exposure to non-inherited maternal antigens (NIMA) in fetal and neonatal life of an F(1) backcross (BDF(1) female × B6 male) mouse can result in lifelong tolerance to allografts expressing the NIMA (H2(d)). We have recently shown that the NIMA-specific regulatory T cells were directly correlated with level of maternal microchimerism (MMc) in adult mice, indicating a causative link between the two, and that both...

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PMID: 21132055
DOI: 10.4161/chim.1.1.12667

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