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Article

Identifying niche-mediated regulatory factors of stem cell phenotypic state: a systems biology approach.

FEBS letters - 1 Feb 2017

Ravichandran Srikanth, Del Sol Antonio

Abstract excerpt

Understanding how the cellular niche controls the stem cell phenotype is often hampered due to the complexity of variegated niche composition, its dynamics, and nonlinear stem cell-niche interactions. Here, we propose a systems biology view that considers stem cell-niche interactions as a many-body problem amenable to simplification by the concept of mean field approximation. This enables approximation of the...

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Identifiers

PMID: 28094442
DOI: 10.1002/1873-3468.12559
PMCID: PMC5324585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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