Article
SPAG6 and L1TD1 are transcriptionally regulated by DNA methylation in non-small cell lung cancers.
Molecular cancer - 5 Jan 2017
Altenberger Corinna, Heller Gerwin, Ziegler Barbara, Tomasich Erwin, Marhold Maximilian, Topakian Thais, Müllauer Leonhard, Heffeter Petra, Lang György, End-Pfützenreuter Adelheid, Döme Balazs, Arns Britt-Madeleine, Klepetko Walter, Zielinski Christoph C, Zöchbauer-Müller Sabine
Abstract excerpt
BACKGROUND: DNA methylation regulates together with other epigenetic mechanisms the transcriptional activity of genes and is involved in the pathogenesis of malignant diseases including lung cancer. In non-small cell lung cancer (NSCLC) various tumor suppressor genes are already known to be tumor-specifically methylated. However, from the vast majority of a large number of genes which were identified to be...
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