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EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival

12 Jan 2017

Abstract excerpt

Subtype-specific human cardiomyocytes (CMs) are valuable for basic and applied research. Induction of cardiomyogenesis and enrichment of nodal-like CMs was described for mouse pluripotent stem cells (mPSCs) in response to 1-ethyl-2-benzimidazolinone (EBIO), a chemical modulator of small-/intermediate-conductance Ca 2+ -activated potassium channels (SKs 1–4). Investigating EBIO in human pluripotent stem cells...

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PMID: 28089668
DOI: 10.1016/j.stemcr.2016.12.012

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