Correlation of chondroitin sulfate proteoglycan expression on proliferating brain capillary endothelial cells with the malignant phenotype of astroglial cells.

Article

Correlation of chondroitin sulfate proteoglycan expression on proliferating brain capillary endothelial cells with the malignant phenotype of astroglial cells.

Cancer research - 15 Sept 1991

Schrappe M, Klier F G, Spiro R C, Waltz T A, Reisfeld R A, Gladson C L

Abstract excerpt

Human glioblastomas (five of five), the most malignant astroglial-derived tumors, specifically express a chondroitin sulfate proteoglycan that is recognized by monoclonal antibody 9.2.27 and localized to the glioma cell surface, proliferating endothelial cells, and the perivascular extracellular matrix within the tumor bed. In contrast, the expression of this proteoglycan in normal adult neocortex and white...

Topics

Antibodies, Monoclonal
Brain
Brain Neoplasms
Capillaries
Cell Division
Chondroitin Sulfate Proteoglycans
Endothelium, Vascular
Glioma
Humans
Medulloblastoma
Phenotype

Tumor Cells, Cultured

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