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Article

Promoter methylation of yes-associated protein (YAP1) gene in polycystic ovary syndrome

1 Jan 2017

Abstract excerpt

BACKGROUND: DNA methylation modification has been proved to influence the phenotype of polycystic ovary syndrome (PCOS). Genome-wide association studies (GWAS) demonstrate that yes-associated protein (YAP1) genetic sites are associated with PCOS. The study aims to detect the methylation status of YAP1 promoter in ovary granulosa cells (GCs) of PCOS patients and explore novel therapeutic targets for PCOS. METHODS:...

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PMID: 28079802
DOI: 10.1097/md.0000000000005768

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