Article
Gene-obesogenic environment interactions in the UK Biobank study.
International journal of epidemiology - 1 Apr 2017
Tyrrell Jessica, Wood Andrew R, Ames Ryan M, Yaghootkar Hanieh, Beaumont Robin N, Jones Samuel E, Tuke Marcus A, Ruth Katherine S, Freathy Rachel M, Davey Smith George, Joost Stéphane, Guessous Idris, Murray Anna, Strachan David P, Kutalik Zoltán, Weedon Michael N, Frayling Timothy M
Abstract excerpt
Background: Previous studies have suggested that modern obesogenic environments accentuate the genetic risk of obesity. However, these studies have proven controversial as to which, if any, measures of the environment accentuate genetic susceptibility to high body mass index (BMI). Methods: We used up to 120 000 adults from the UK Biobank study to test the hypothesis that high-risk obesogenic environments and...
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