An atlas of early human mandibular endochondral and osteogenic paracrine signaling regions of Meckel’s cartilage

Abstract excerpt

The mandible, also known as the lower jaw, is the only bone in the skull that can move and is essential for speaking and chewing. Meckel’s cartilage (MC) is a temporary structure that supports the formation of the mandible, but how MC is involved in the ossification of the mandible is poorly understood. Through the use of single-cell RNA sequencing and single-cell spatial transcriptomics analyses, a...

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