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Article

Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2017

Krishna Smriti Murali, Seto Sai-Wang, Jose Roby J, Li Jiaze, Morton Susan K, Biros Erik, Wang Yutang, Nsengiyumva Vianne, Lindeman Jan H N, Loots Gabriela G, Rush Catherine M, Craig Jeffrey M, Golledge Jonathan

Abstract excerpt

OBJECTIVE: Sclerostin (SOST) has been identified as an important regulator of bone formation; however, it has not been previously implicated in arterial disease. The aim of this study was to assess the role of SOST in aortic aneurysm (AA) and atherosclerosis using human samples, a mouse model, and in vitro investigations. APPROACH AND RESULTS: SOST protein was downregulated in human and mouse AA samples compared...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28062506
DOI: 10.1161/ATVBAHA.116.308723

Genes

SOST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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