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Innate immunity to mycobacteria: vitamin D and autophagy

14 Jun 2010

Abstract excerpt

Autophagy is an ancient mechanism of protein degradation and a novel antimicrobial strategy. With respect to host defences against mycobacteria, autophagy plays a crucial role in antimycobacterial resistance, and contributes to immune surveillance of intracellular pathogens and vaccine efficacy. Vitamin D3 contributes to host immune responses against Mycobacterium tuberculosis through LL-37/hCAP-18, which is the...

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PMID: 20557314
DOI: 10.1111/j.1462-5822.2010.01491.x

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