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Article

A Combination of Naltrexone + Varenicline Retards the Expression of a Genetic Predisposition Toward High Alcohol Drinking.

Alcoholism, clinical and experimental research - 1 Mar 2017

Froehlich Janice C, Fischer Stephen M, Nicholson Emily R, Dilley Julian E, Filosa Nicholas J, Smith Teal N, Rademacher Logan C

Abstract excerpt

BACKGROUND: This study examined whether naltrexone (NTX) or varenicline (VAR), alone or in combination, can retard the phenotypic expression of a genetic predisposition toward high alcohol drinking in rats selectively bred for high alcohol intake when drug treatment is initiated prior to, or concomitantly with, the onset of alcohol drinking. METHODS: Alcohol-naïve P rats were treated daily with NTX (15.0 mg/kg...

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Source

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Identifiers

PMID: 28055135
DOI: 10.1111/acer.13326
PMCID: PMC5332282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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