Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lower Frequency of HLA-DRB1 Type 1 Diabetes Risk Alleles in Pediatric Patients with MODY.

PloS one - 1 Jan 2017

Urrutia Inés, Martínez Rosa, López-Euba Tamara, Velayos Teresa, Martínez de LaPiscina Idoia, Bilbao José Ramón, Rica Itxaso, Castaño Luis

Abstract excerpt

OBJECTIVE: The aim of this study was to determine the frequency of susceptible HLA-DRB1 alleles for type 1 diabetes in a cohort of pediatric patients with a confirmed genetic diagnosis of MODY. MATERIALS AND METHODS: 160 families with a proband diagnosed with type 1 diabetes and 74 families with a molecular diagnosis of MODY (61 GCK-MODY and 13 HNF1A-MODY) were categorized at high definition for HLA-DRB1 locus....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Diabetes Mellitus, Type 2

Share to Gene Frequency

Share to HLA-DRB1 Chains

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 28052112
DOI: 10.1371/journal.pone.0169389
PMCID: PMC5214860

Genes

GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lower Frequency of HLA-DRB1 Type 1 Diabetes Risk Alleles in Pediatric Patients with MODY.PMID 28052112Read ↗

MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants.Semantic proximity Read ↗

Substantial proportion of MODY among multiplex families participating in a Type 1 diabetes prediction programme.Semantic proximity Read ↗

Study of the frequency and clinical features of maturity-onset diabetes in the young in the pediatric and adolescent diabetes population in Iran.Semantic proximity Read ↗

Clinical application of ACMG-AMP guidelines in HNF1A and GCK variants in a cohort of MODY families.Semantic proximity Read ↗

Identification Of Pathogenic Mutations And Application Of Polygenic Risk Scores To Differentiate MODY Patients From Other Diabetes TypesSemantic proximity Read ↗

Phenotypical aspects of maturity-onset diabetes of the young (MODY diabetes) in comparison with Type 2 diabetes mellitus (T2DM) in children and adolescents: experience from a large multicentre database.Semantic proximity Read ↗

Genetic basis of early-onset, maturity-onset diabetes of the young-like diabetes in Japan and features of patients without mutations in the major MODY genes: Dominance of maternal inheritanceSemantic proximity Read ↗

Whole Exome Sequencing in Children With Type 1 Diabetes Before Age 6 Years Reveals Insights Into Disease Heterogeneity.Semantic proximity Read ↗

Asian MODY: are we missing an important diagnosis?Semantic proximity Read ↗

When do we need to suspect maturity onset diabetes of the young in patients with type 2 diabetes mellitus?Semantic proximity Read ↗

Pathogenic variants of MODY-genes in adult patients with early-onset type 2 diabetes.Semantic proximity Read ↗

Molecular background and clinical characteristics of HNF1A MODY in a Polish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.