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MicroRNA-224 delays oocyte maturation through targeting Ptx3 in cumulus cells

28 Dec 2016

Abstract excerpt

MicroRNAs (miRNAs) have been improved to regulate oocyte development in a cell- or stage-specific manner. In this study, we aimed to clarify microRNA-224's (miR-224) role in cumulus cells (CCs), to find out whether a change level of miR-224 in CCs could influence the maturation of oocyte. We found that overexpression of miR-224 of CCs led to the impairment of cell expansion, along with a decrease in the gene...

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PMID: 28039065
DOI: 10.1016/j.mod.2016.12.004

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