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Manipulating virulence factor availability can have complex consequences for infections

13 Sept 2016

Abstract excerpt

Abstract Given the rise of bacterial resistance against antibiotics, we urgently need alternative strategies to fight infections. Some propose we should disarm rather than kill bacteria, through targeted disruption of their virulence factors. It is assumed that this approach (i) induces weak selection for resistance because it should only minimally impact bacterial fitness, and (ii) is specific, only interfering...

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PMID: 28035238
DOI: 10.1111/eva.12431

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