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Article

TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications.

PloS one - 1 Jan 2012

Yin Jieyun, Li Yangkai, Yin Ming, Sun Jingwen, Liu Li, Qin Qin, Li Xiaorong, Long Lu, Nie Shaofa, Wei Sheng

Abstract excerpt

BACKGROUND: Some common genetic variants of TERT-CLPTM1L gene, which encode key protein subunits of telomerase, have been suggested to play a crucial role in tumorigenesis. The TERT-CLPTM1L polymorphism rs401681 was of special interest for cancers risk but with inconclusive results. METHODOLOGY/PRINCIPAL FINDINGS: We performed a comprehensive meta-analysis of 29 publications with a total of 91263 cases and 735952...

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Identifiers

PMID: 23226346
DOI: 10.1371/journal.pone.0050650
PMCID: PMC3511286

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TERT-CLPTM1L polymorphism rs401681 contributes to cancers risk: evidence from a meta-analysis based on 29 publications.PMID 23226346Read ↗

Genetic variants in TERT-CLPTM1L genetic region associated with several types of cancer: a meta-analysis.Semantic proximity Read ↗

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.Semantic proximity Read ↗

Association between CLPTM1L-TERT rs401681 polymorphism and pancreatic cancer risk among Chinese Han population.Semantic proximity Read ↗

Association between CLPTM1L-TERT rs401681 polymorphism and risk of pancreatic cancer: a meta-analysis.Semantic proximity Read ↗

Association between TERT-CLPTM1L rs401681[C] allele and NMSC cancer risk: a meta-analysis including 45,184 subjects.Semantic proximity Read ↗

Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.Semantic proximity Read ↗

Association between TERT rs2853669 polymorphism and cancer risk: A meta-analysis of 9,157 cases and 11,073 controls.Semantic proximity Read ↗

Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis.Semantic proximity Read ↗

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The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma.Semantic proximity Read ↗

The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis.Semantic proximity Read ↗

TERT-CLPTM1L Rs401681 C>T polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population.Semantic proximity Read ↗

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