Article
Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia.
Atherosclerosis - 1 Jan 2017
Christensen Jacob J, Osnes Liv T, Halvorsen Bente, Retterstøl Kjetil, Bogsrud Martin P, Wium Cecilie, Svilaas Arne, Narverud Ingunn, Ulven Stine M, Aukrust Pål, Holven Kirsten B
Abstract excerpt
BACKGROUND AND AIMS: Children with familial hypercholesterolemia (FH) have elevated LDL cholesterol from the first year of life, and represent a model of early-stage atherosclerosis. Data suggest that adults with FH have alterations in circulating monocyte subpopulations towards a more pro-inflammatory phenotype, but it is not known whether FH children have similar perturbations. In addition, there are no data on...
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