Article
Association of KCNJ2 Genetic Variants with Susceptibility to Thyrotoxic Periodic Paralysis in Patients with Graves' Disease.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Feb 2017
Park Suyeon, Kim Tae Yong, Sim Soyoung, Oh Hye-Seon, Song Eyun, Kim Mijin, Kwon Hyemi, Choi Yun Mi, Jeon Min Ji, Kim Won Gu, Shong Young Kee, Kim Won Bae
Abstract excerpt
Objective: Thyrotoxic periodic paralysis (TPP) is characterized by acute onset paralysis and hypokalemia predominantly in male patients with thyrotoxicosis. Recent studies have emphasized the importance of potassium channels, which might explain the underlying mechanism of TPP. The KCNJ2 gene encodes the inward-rectifying potassium channel. In this study, we evaluated the role of KCNJ2 in the development of TPP....
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