Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis.

doi:10.1016/j.cell.2009.12.024

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Article

Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis.

Cell - 8 Jan 2010

Ryan Devon P, da Silva Magnus R Dias, Soong Tuck Wah, Fontaine Bertrand, Donaldson Matt R, Kung Annie W C, Jongjaroenprasert Wallaya, Liang Mui Cheng, Khoo Daphne H C, Cheah Jin Seng, Ho Su Chin, Bernstein Harold S, Maciel Rui M B, Brown Robert H, Ptácek Louis J

Abstract excerpt

Thyrotoxic hypokalemic periodic paralysis (TPP) is characterized by acute attacks of weakness, hypokalemia, and thyrotoxicosis of various etiologies. These transient attacks resemble those of patients with familial hypokalemic periodic paralysis (hypoKPP) and resolve with treatment of the underlying hyperthyroidism. Because of the phenotypic similarity of these conditions, we hypothesized that TPP might also be a...

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Topics

Amino Acid Sequence
Base Sequence
DNA Mutational Analysis
Electrophysiological Phenomena
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Hypokalemic Periodic Paralysis

Molecular Sequence Data

Mutation

Potassium Channels, Inwardly Rectifying

Transcription, Genetic

Triiodothyronine

Source

Open in PubMed Open full text

Identifiers

PMID: 20074522
DOI: 10.1016/j.cell.2009.12.024
PMCID: PMC2885139

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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