Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3.

doi:10.1038/ng.2367

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Article

Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3.

Nature genetics - 1 Sept 2012

Cheung Ching-Lung, Lau Kam-Shing, Ho Andrew Y Y, Lee Ka-Kui, Tiu Sau-Cheung, Lau Emmy Y F, Leung Jenny, Tsang Man-Wo, Chan Kin-Wah, Yeung Chun-Yip, Woo Yu-Cho, Cheung Elaine Y N, Hung Victor H F, Pang Ho-Kwong, Hung Chi-Sang, Sham Pak-Chung, Kung Annie W C

Abstract excerpt

Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of thyrotoxicosis. We conducted a genome-wide association study (GWAS) and a replication study with a total of 123 southern Chinese with TPP (cases) and 1,170 healthy controls and identified a susceptibility locus on chromosome 17q24.3 near KCNJ2 (rs312691: odds ratio (OR) = 3.3; P(meta-analysis) = 1.8 × 10(-14)). All subjects with...

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Identifiers

PMID: 22863731
DOI: 10.1038/ng.2367

Genes

KCNJ2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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