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Article

Influence of Polymorphisms in the HTR3A and HTR3B Genes on Experimental Pain and the Effect of the 5-HT3 Antagonist Granisetron.

PloS one - 1 Jan 2016

Louca Jounger Sofia, Christidis Nikolaos, Hedenberg-Magnusson Britt, List Thomas, Svensson Peter, Schalling Martin, Ernberg Malin

Abstract excerpt

The aim of this study was to investigate experimentally if 5-HT3 single nucleotide polymorphisms (SNP) contribute to pain perception and efficacy of the 5-HT3-antagonist granisetron and sex differences. Sixty healthy participants were genotyped regarding HTR3A (rs1062613) and HTR3B (rs1176744). First, pain was induced by bilateral hypertonic saline injections (HS, 5.5%, 0.2 mL) into the masseter muscles. Thirty...

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Identifiers

PMID: 28002447
DOI: 10.1371/journal.pone.0168703
PMCID: PMC5176308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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