Article
Genetic polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 promoter may not be associated with development of hepatocellular carcinoma.
Scientific reports - 21 Dec 2016
Zhu Shao-Liang, Zhao Yun, Hu Xue-Ying, Luo Tao, Chen Zu-Shun, Zhang Yu, Yang Shui-Hua, Zhou Lu, Li Le-Qun
Abstract excerpt
This study meta-analyzed the literature on possible association of polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 (IL-18) promoter with risk of hepatocellular carcinoma (HCC). The analysis included 8 case-control studies on the -137 polymorphism (1,318 cases, 2,254 controls) and 7 case-control studies on the -607 polymorphism (1,262 cases, 1,696 controls). None of the five genetic models...
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