Article
Characterization of IFNγ-producing natural killer cells induced by cytomegalovirus reactivation after haploidentical hematopoietic stem cell transplantation.
Oncotarget - 3 Jan 2017
Jin Fengyan, Lin Hai, Gao Sujun, Wang Hengxiang, Yan Hongmin, Guo Jinglong, Hu Zheng, Jin Chunhui, Wang Yongqi, Wang Zhidong, Zhao Yangzhi, Liu Yu, Zheng Xiaoli, Tan Yehui, Li Wei, Dai Yun, Yang Yanping
Abstract excerpt
During human cytomegalovirus (CMV) infection after umbilical cord blood or HLA-matched hematopoietic stem cell transplantation (HSCT), a population of NKG2C-expressing natural killer (NK) cells expand and persist. The expanded NK cells express high levels of inhibitory killer immunoglobulin-like receptors (KIR) specific for self-HLA and potently produce IFNγ. However, it remains unknown whether similar events...
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