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Article

Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation.

JCI insight - 8 Feb 2022

Yu Xing-Xing, Shang Qian-Nan, Liu Xue-Fei, He Mei, Pei Xu-Ying, Mo Xiao-Dong, Lv Meng, Han Ting-Ting, Huo Ming-Rui, Zhao Xiao-Su, Chang Ying-Jun, Wang Yu, Zhang Xiao-Hui, Xu Lan-Ping, Liu Kai-Yan, Zhao Xiang-Yu, Huang Xiao-Jun

Abstract excerpt

CMV infection remains an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Several investigators have reported that adaptive NKG2C+ NK cells persistently expand during CMV reactivation. In our study, 2 cohorts were enrolled to explore the relationships among the NKG2C genotype, NKG2C+ NK cell reconstitution, and CMV infection. Multivariate analysis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34990406
DOI: 10.1172/jci.insight.149120
PMCID: PMC8855817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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