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Article

Impact of genetic and nongenetic factors on interindividual variability in 4β-hydroxycholesterol concentration.

European journal of clinical pharmacology - 1 Mar 2017

Hole Kristine, Gjestad C, Heitmann K M, Haslemo T, Molden E, Bremer S

Abstract excerpt

PURPOSE: Individual variability in the endogenous CYP3A metabolite 4β-hydroxycholesterol (4βOHC) is substantial, but to which extent this is determined by genetic and nongenetic factors remains unclear. The aim of the study was to evaluate the explanatory power of candidate genetic variants and key nongenetic factors on individual variability in 4βOHC levels in a large naturalistic patient population. METHODS: We...

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PMID: 27975131
DOI: 10.1007/s00228-016-2178-y

Genes

POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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